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Marly Skin Guard™ Clinical Studies

TUFTS UNIVERSITY
School of Dental Medicine

Pilot Study: A Skin Protectant for Latex glove induced Dermal Sensitivity Reactions. W. BEABER, N. ARBREE, and G. KUGEL (Tufts University School of Dental Medicine, Boston, MA) November 1995
The Study

Latex glove induced dermal reactions are a significant problem for a growing percentage of the dental community. The purpose of this study was to determine if a commercially available foam barrier could effectively block dermal irritations caused by latex gloves. Fifteen subjects with known latex glove dermal sensitivities and fifteen subjects with no known latex glove dermal sensitivities were tested. In both groups, one hand was tested with the MARLY SKIN GUARDfoam barrier and the other hand was left barrier free. All subjects followed the same techniques of washing both hands with an oil free soap (0.4 Chlorhexadine), drying both hands, placing a glove on the non barrier hand to act as a shield to apply the foam barrier to the non-gloved surfaces of the barrier hand, and allowing the foam to dry for four minutes. The person donned and removed latex gloves, washed their hands, and performed various associated tasks as needed for up to four hours (barrier stops protecting after four hours). If they were going to continue wearing latex gloves, the technique for foam barrier application was repeated every four hours. This process was repeated daily under dental office conditions for two weeks. Persons were monitored daily for potential symptoms on both hands. Each hand was graded according to a system based on the demonstrated dermatological symptoms. Persons with latex glove sensitivities that developed reactions on the unprotected hand were switched to non latex gloves for the remainder of the study.

Results

In the known sensitivity group, 12 of 15 developed symptoms on the unprotected hand; 15 of 15 were symptom free on the protected hand. In the no known sensitivity group, 15 of 15 were symptom free on the unprotected hand; 15 of 15 were symptom free on the protected hand. There were no symptoms in any sensitive individuals after using the foam barrier for two weeks. Data was analyzed using McNemar's test (p<0.01). The results of this study seem to indicate that MARLY SKIN GUARD foam barrier is an effective protectant against latex glove induced dermal sensitivity reactions.


Additional Clinical Report Summaries

1) PROF. DR. MED. FUeHRER – “Protective Efficacy and composition of Marly Skin GUARD™

Institute of Pharmaceutical Engineering of the Technical University, Braunschweig

2) PROF. DR. MED. stresemann – “A new skin protection Principle in hazardous occupations”

Director of the Institute for Occupational and Social Medical Allergy Diagnostics at the Erich-Schuetz-Research-Institute of the State Spa of Salzuflen at the Wilhelms-University in Muenster, Westfalia

3) PROF. DR. MED. schöpf | Prof. dr. med. niedner – “alkaline resistance test”

Albert-Ludwigs-University-Hospital in Freiburg, Dermatological University Clinic

4) PROF. DR. MED. springorum – “Pre-Operative skin sealing instead of conventional plastic foils”

Medical Superintendent of the Orthopaedic Clinic, Caritas Hospital, Bad Mergentheim

5) DR. MED. talke – “Plaster Allergies”

Orthopaedist and Rheumatologist, Berlin

6) PROF. DR. MED. jung – “Light-Dependent Skin Reactions”

Full Professor at the University of Heidelberg and Medical Director of the Dermatological Hospital of the City of Mannheim

7) PROF. DR. MED. wille – “Hand disinfection”

Institute of Hospital Hygiene and Infection Control, Giessen

8) PROF. DR. Friedrich | Dr. Effendy – “Mycological Studies”

Philipps-University of Marburg, Medical Centre for Dermatological Diseases

9) PROF. DR. MED. plewig – “allergy testing with sodium lauryl sulFate and dimethyl sulFoxide”

Medical Facilities of the University of Düsseldorf, Director of the Dermatological Hospital

10) PROF. DR. MED. Otten – “sugery”

Medical Superintendent of the Surgical Clinic of the DRK-Hospitals of Wesermuende

11) Prof. DR. MED. tronnier – “Allergy test – determination of protection factors”

Medical Director of the Dermatological Hospital, Dortmund

12) DR. MED. redecker – “Decubital ulcers and pruritus in the urological Sector”

Urologist, Bruchsal

13) Prof. dr. bössmann – “contamination experiments”

Hospital of the Christian-Albrecht-University of Kiel, Centre of Oral medicine, Department of Conservative Dentistry

14) Prof. dr. bössmann – “contamination experiments”

Hospital of the Christian-Albrecht-University of Kiel, Centre of Oral medicine, Department of Conservative Dentistry

15) PROF. DR. MED. wilhelm – “Hand Desinfection”

Director of the Hand-Surgical Department Surgical City Hospital and Surgical Clinic for Outpatients, University of Munich

16) dr. Med. Baumann – “Decubitus”

Herz-Jesu-Hospital, Vienna

17) Univ. Prof. DR. MED. RAAB – “occupational Dermatoses”

Dermatologist, Vienna

18) priv.-doz. dr. Med. R. heinrich – “Decubitus”

Medical-Geriatric Clinic, University Hospital of Herne

19) Univ. Doz. dr. med. aberer – “Housewife‘s eczema”

Medical Director of the Allergy Outpatient Department, I. University Dermatological Hospital of Vienna

20) priv.-doz. dr. med. wischhöfer – “Burns, decubital ulcers”

Surgeon and Accident Surgeon Chief Medical Superintendent, Kösching District Hospital

21) dr. med. grobe – “Skin protection with wine-Growers”

Dermatologist and Venerologist, Trier (Special edition in: DER DEUTSCHE DERMATOLOGE)

22) priv.-doz. dr. med. rudolph – “neurodermATitis”

Dermatologist and Allergist Chief Medical Superintendent, North Sea Hospital, Norderney

23) dr. Med. bescher – “Diaper dermatitis”

Paediatrician, Bensheim

24) PROF. DR. MED. weissenbacher – “Skin irritions in gynaecology (vulva)”

Ludwig-Maximilians-University of Munich, Clinic of Grosshadern – Gynaecological Dept. Munich

25) Univ. Prof. dr. dr. med. schwanitz – “skin protection from permanent wave fluid”

University of Osnabrück, Commission of medical health sciences

26) dr. med. lutfi – “perianal Eczema - irritative dermatitis”

Medical Superintendent of the Colo-Proctological Clinic, Marien hospital, Bottrop, Surgery II

27) prof. dr. med. fuesgen – “prevention of skin damage in elderly immobilized patients”

Chair of Geriatrics of the University of Witten-Herdecke and Medical Superintendent of the 3rd Medical Hospital, St. Antonius Clinics, Velbert Publication in the journal GERIATRIE PRAXIS

28) prof. dr. med. knopf – “empirical report on the use of Marly Skin GUARD™ in occupational practice”

Friedrich-Schiller-University of Jena, Department of Medicine,

Hospital and Outpatient Clinic for Skin Diseases

29) prim. Univ. Doz. dr. Med. Zechmann – “Handling of minor radioactive substances”

Institute for Nuclear Medicine and Thyroid Diagnostics, Wörgl/Austria

30) DR. MED. duschet | prof. dr. med. gschnait – “Skin protection in the surroundings of VENOUS ULCERS”

Dermatological Dept., Vienna-Lainz Hospital

31) Univ. Doz. dr. med. chlud – “controlled pharmacokinetic investigations of the percutane penetration-inhibiting effect of oestrogen by a skin protector Marly Skin GUARD™

Kaiser-Franz-Joseph-Spital of Vienna, II. Med. Dept. of Rheumatology and Osteology, Publication in the journal THERAPIEWOCHE

32) prof. dr. med. vanscheidt – “liquid absorbing capacity of diapers after local skin pretreatment with various topical preperations”

Albert-Ludwigs-University-Hospital of Freiburg, Dermatological University Clinic

33) prof. dr. med. rufli – “Annotated summary of experiences with the skin protector Marly Skin GUARD™

Director of the Dermatological University Clinic, Cantonal Hospital, Basel/Switzerland

All rights reserved. The use of any part of these reports reproduced, transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, or stored in a retrieval system, or translated into other languages, is not permitted without prior written consent of Marly Products, S. Behre-Monien.

With more than 200 written reports and over 40 clinically controlled studies conducted by renowned doctors and scientists in multiple universities since 1988, makes Marly Skin Guard the most documented skin barrier product in the world.